Shay Given is likely to win a 109th international cap against Wales in the Celtic Nations cup next month while Seamus Coleman and Ciaran Clark could be in line for their first after Giovanni Trapattoni's provisional 29-man squad announcement in Dublin yesterday.
Given has endured a frustrating season at Manchester City, playing in just four of his side's games this season after manager Roberto Mancini opted for England international Joe Hart, but the Lifford native has been an ever present in Ireland's games this term.
Coleman, meanwhile, has had a fruitful campaign at Everton, so much so the 22-year-old last week signed an improved contract at the Goodison Park outfit until 2015.
It is the third time the Killybegs native has been named in the Irish squad, having been drafted in for the European Championship qualifier double-header against Russia and Slovakia in October, as well as earning a place for the November friendly international loss to Norway at the Aviva Stadium in November. That night he was an unused substitute.
London born Clark, a defender-cum-midfielder from Aston Villa, was also a late call-up for that game, but a calf injury sustained beforehand forced a withdrawal. The 20-year-old, who had captained England at underage level, switched his allegiances last year to Ireland.
His father Michael, although born in Edinburgh when his family were working in Scotland for a time, is a former student of Drummond National School in Ballyare and played for Milford United under Fr Michael Herrity as a teenager.
Michael eventually decided to move to England to find work and his wife Peggy, from Drumshambo, Co Leitrim, who trained as a nurse in Letterkenny General Hospital, left with him in early 1989.
However, two other men with Donegal connections have been overlooked. Shane Duffy from Everton is a native of Derry whose father Brian is from Letterkenny has been overlooked, as has James McCarthy from Wigan Athletic.
Despite appearing on the bench for his side in their 3-0 loss at Arsenal at the Emirates on Saturday after recovering from an ankle injury that had kept him sidelined since October, McCarthy, who qualifies for Ireland as his late grandfather Packie Coll was from Gweedore, will have to wait to add to the cap he earned against Brazil last year in London.
Ireland provisional squad v Wales: Shay Given, Keiren Westwood, John O'Shea, Ciaran Clark, Seamus Coleman, Richard Dunne, Sean St. Ledger, Kevin Foley, Kevin Kilbane, Stephen Kelly, Darren O'Dea, Paul McShane, Marc Wilson, Darron Gibson, Glenn Whelan, Paul Green, Liam Lawrence, Stephen Hunt, Aiden McGeady, Keith Treacy, Damien Duff, Keith Fahey, Robbie Keane, Jonathan Walters, Kevin Doyle, Shane Long, Andy Keogh, Leon Best, Anthony Stokes.