The N15 is closed between Donegal Town and Ballyshannon following a collision at Laghey.
Gardaí in Ballyshannon said the collision took place at around 5pm.
An eyewitness told the Democrat that up to three vehicles were involved in the crash which occurred about 200 metres south of Kee’s of Laghey.
Gardaí, ambulance and fire services are all at the scene.
Diversions are in place and gardaí are advising motorists to slow down and expect delays in the area.
More details as we get them.